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Human IA-2 (ICA 512) Antigen

Recombinant Human IA-2 (ICA 512) Antigen was expressed by baculovirus in Sf9 insect cells and purified by affinity chromatography using a His tag.

HIA01-F23H
100 µg1 mg Bulk Customize

$ 260

*The image is illustrative and does not necessarily represent the product


Alternate Names:

PTP IA-2, Islet cell autoantigen 3, Islet cell antigen 512


Formulation:

Protein stored in 50 mM sodium phosphate, pH 8.0, 20% Glycerol


References:

1. Notkins AL, et al. IA-2 and IA-2 beta are major autoantigens in IDDM and the precursors of the 40 kDa and 37 kDa tryptic fragments. J Autoimmun. 1996 Oct;9(5):677-82.

2. Solimena M, et al. ICA 512, an autoantigen of type I diabetes, is an intrinsic membrane protein of neurosecretory granules. EMBO J. 1996 May 1;15(9):2102-14.

3. Verge CF, et al. Prediction of type I diabetes in first-degree relatives using a combination of insulin, GAD, and ICA512bdc/IA-2 autoantibodies. Diabetes. 1996 Jul;45(7):926-33.

Storage and Stability:

Store at –70°C. To avoid repeated handling and multiple freeze/thaw cycles, aliquot product into smaller quantities


Source:

Homo Sapiens (Human)


Host:

Baculovirus-infected Sf9 insect cells


Molecular weight:

Calculated: 46 kDa
Observed: ~46 kDa


Purity:

The purity was determined to be ≥ 85% by densitometry




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