β-Thionicotinamide Adenine Dinucleotide oxidized form free acid (β-Thio-NAD)

Alternate Names:

β-Thionicotinamide Adenine Dinucleotide oxidized form free acid, β-Thio-NAD, Thionicotinamide-DPN oxidized form

Overview:

β-thionicotinamide adenine dinucleotide (β-Thio-NAD) is an analog of the coenzyme nicotinamide adenine dinucleotide (NAD) (1). β-Thio-NAD is reduced to β thio-NADH. β-Thio-NAD It is used for various clinical chemistry applications, including determining the levels of L-cartenine in serum by an enzymatic cycling method (2), ultrasensitive sandwich enzyme-linked immunosorbent assay (ELISA) assays for detection of infectious disease (3).

References:

1. National Center for Biotechnology Information (2022). PubChem Compound Summary for CID 3081386, Thio-NAD. Retrieved October 24, 2022 from https://pubchem.ncbi.nlm.nih.gov/compound/Thio-NAD.
2. M Takahashi, S Ueda, H Misaki, N Sugiyama, K Matsumoto, N Matsuo, S Murao, Carnitine determination by an enzymatic cycling method with carnitine dehydrogenase, Clinical Chemistry, Volume 40, Issue 5, 1 May 1994, Pages 817- 821, https://doi.org/10.1093/clinchem/40.5.817
3. Iha K, Inada M, Kawada N, Nakaishi K, Watabe S, Tan YH, Shen C, Ke LY, Yoshimura T, Ito E. Ultrasensitive ELISA Developed for Diagnosis. Diagnostics (Basel). 2019 Jul 18;9(3):78. doi: 10.3390/diagnostics9030078. PMID: 31323782; PMCID: PMC6787603.

Storage and Stability:

Product can be stored at ambient sealed, dry and protected from light for transportation process but long-term storage should be at –20°C in tightly closed contains, protected from humility.

CAS:

4090-29-3

Molecular Formula:

C21H27N7O13SP2

Appearance:

Yellow powder

Molecular Weight:

679.49 g/mol

Purity Analysis:

Purity: ≥ 95% (HPLC)
Assay: ≥95 % (UV) (calculated on a dry basis)
Sodium Content: ≤ 1%
Water Content: ≤ 5%

pH of Solution:

2.0-4.0 (100 mg/mL water)